MOOC: Validation of liquid chromatography mass spectrometry (LC-MS) methods (analytical chemistry) course

Self test 9.2

If the analysis result is above CC_β then the following statement can be made: The analyte is detected and present in the sample.

True

False

If the analysis result is below CC_α then the following statement can be made: The analyte level is below CC_α.

False

True

Which of the following statements are true:

False negative results are results that are by random below CC_α but the best estimate of the sample is really above CC_α.

If the best estimate of a measured sample is exactly at CC_α then 50% of the measurement results will be falsely interpreted as negative.

False positive results are results that are by random below CC_α but the best estimate is really above CC_α.

The CC_α of the method is 0.05 mg/kg and CC_β is 0.075 mg/kg. Therefore it can be stated that this method can detect analytes at 0.05 mg/kg with good probability.

True

False