MOOC: Validation of liquid chromatography mass spectrometry (LC-MS) methods (analytical chemistry) course

Self test 4.4B

1.

You are validating a method of analysis of Glyphosate in surface water. Using data from analyzing your control sample, evaluate intermediate precision.

Date C (μg/L) Chemist
16.06.15 0.20 Ramon
17.06.15 0.21 Ramon
25.08.15 0.15 Ramon
25.08.15 0.18 Ramon
26.08.15 0.19 Ramon
31.08.15 0.20 Ramon
31.08.15 0.17 Ramon
3.09.15 0.18 Ramon
7.09.15 0.18 Ramon
14.09.15 0.19 Ramon
25.09.15 0.14 Susan
12.10.15 0.17 Ramon
27.10.15 0.13 Susan
17.12.15 0.15 Susan
22.02.16 0.13 Susan
29.02.16 0.15 Susan
11.04.16 0.13 Susan

 

Insert results with units!

2.

Is it important to know the exact concentration of Glyphosate in the sample?

3.

What is the relative intermediate precision of the method (in %)?

[accordion][acctitle]Clue[/acctitle]Standard deviation is 0.0266 μg/L[/accordion]

4.

What could be the reasons for observing decreasing Glyphosate concentration in the control chart (check all that apply)?


 

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