Validation of liquid chromatography mass spectrometry (LC-MS) methods
12.1 Certified Reference Materials and their Production
In case you wish to learn more about certified reference materials (CRMs), their use and production, you are welcome to watch two-part lecture by Dr. Burcu Binici from TÜBITAK UME:
production based on the ISO 17034, Part 1: Basics, definitions, types and properties of CRMs; selection handling and storage of CRMs; evaluation of method performance using CRMs; production requirements of CRMs; main steps in CRM production; material handling, processing and storage; metrological traceability of CRM certified values.
CRM production based on the ISO 17034, Part 2: Homogeneity of CRM material, evaluation of homogeneity, uncertainty due to homogeneity; evaluation of , uncertainty due to limited stability; CRM characterisation strategies; uncertainty of CRM reference values; labelling CRMs; CRM certificates; examples of CRM production.
The slides of the lectures are available from here.
These learning materials were created as part of the European Metrology Partnership project 23IND13 ScreenFood “Metrology for food safety in the circular economy”.
