Validation of liquid chromatography mass spectrometry (LC-MS) methods

Self test 2.2

What are the main advantages of MS as detector in liquid chromatography?

1. MS detector enables low limits of detection

2. MS detector is inexpensive

3. MS detector enables high selectivity

4. MS detector enables high quantitative accuracy

5. MS detector enables reliable identification of the analyte

6.

MS is often operated without LC for analysis of real sample mixtures.

7.

MS is a selective detector. To further increase its selectivity high resolution MS or tandem MS (MS/MS) are used.


 

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