Validation of liquid chromatography mass spectrometry (LC-MS) methods

Glossary

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MRL

Maximum residue limit: the maximum allowed concentration limit set for the compound in certain matrices.

Measurement uncertainty

Measurement uncertainty (or simply uncertainty) defines an interval around the measured value CMEASURED, where the true value CTRUE lies with some predefined probability. The measurement uncertainty U itself is the half-width of that interval and is always non-negative. This definition differs from the VIM [ref 6] definition (but does not contradict it) and we use it here as it is generally easier to understand and to relate to practice.

Method LoD

LoD estimated by using matrix matched samples that are put through the whole analysis method (including the sample preparation).

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