Validation of liquid chromatography mass spectrometry (LC-MS) methods

Glossary

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Linear range

Range of concentrations where the signals are directly proportional to the concentration of the analyte in the sample.

Linearity

Methods ability to obtain signals, which are directly proportional to the concentration of analyte in the sample.

LoD

Limit of detection: the smallest amount or concentration of analyte in the test sample that can be reliably distinguished from zero.

LoQ

Limit of quantitation: the lowest concentration of analyte that can be determined with an acceptable repeatability and trueness.