Validation of liquid chromatography mass spectrometry (LC-MS) methods

Glossary

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Identity confirmation

Providing evidence that the analytical signal registered during sample analysis is due to analyte and not any other (interfering) compound.

Instrumental LoD

LoD estimated for the analysis instrument by measuring the analyte from pure solvent without any sample pretreatment.

Intermediate precision

The precision obtained within a single laboratory over a longer period of time (generally at least several months).