Validation of liquid chromatography mass spectrometry (LC-MS) methods

Glossary

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CCα

Decision limit: the concentration level, as determined by the method, at which there is probability α (usually defined as 0.05 or 5%) that a blank sample will give a signal at this level or higher. 

CCβ

Detection capability:  the concentration level of the analyte in sample at which there is probability β (again usually defined as 0.05 or 5%) that the method will give a result lower than CCα, meaning that the analyte will be declared as undetected.

CRM

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