Validation of liquid chromatography mass spectrometry (LC-MS) methods

Glossary

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Accuracy

Measurement result accuracy indicates its closeness to the true value.

Analytical run

or simply run:

Definition 1: A set of samples that are analysed in one batch, during short time. In LC and LC-MS this term typically refers to an automatized sequential analysis of a set of samples, calibrants and QC samples that have been loaded into autosampler.

Definition 2 (defined by Clinical Laboratory Improvement Amendments (CLIA)): An interval (i.e., a period of time or series of measurements) within which the accuracy and precision of the measuring system is expected to be stable. In laboratory operations, control samples are analyzed during each analytical run to evaluate method performance, therefore the analytical run defines the interval (period of time or number of specimens) between evaluations of control results. Between quality control evaluations, events may occur causing the measurement process to be susceptible to variations that are important to detect.

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