Validation of liquid chromatography mass spectrometry (LC-MS) methods

Self test 2.4

What makes MS detector in LC-MS a more useful tool for analyte identity confirmation than UV-Vis photodiode array detector?

1. Mass spectra of compounds obtained with the common LC-MS ion sources are usually more characteristic than UV-Vis spectra

2. MS detector enables higher quantitative accuracy than UV-Vis detector

3. MS detector has MSn possibilities

4. MS detector’s ability of analyte identification is less influenced by peak overlap

5. LC separation of isomeric forms of A and B was not successful and MS/MS spectra of A and B were identical. Can HRMS help to achieve selectivity between A and B?

 


 

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