Centre of Excellence In Molecular Cell Engineering
Engineering biosynthesis pathways and circuits
WP leader: Mart Loog
General concept. New pathways for the production of biomolecules (biochemicals, antibodies, other proteins) will be introduced into bacterial, yeast, plant and mammalian cells.
Projects
- A1. Engineering protein production pathways
- A2. Synthetic protein tags and regulatory circuits
- A3. Engineering the isoprenoid biosynthesis pathway
Long‐term goal
To create a platform that would enable engineering of metabolic pathways. This will be achieved by transferring genes into standard expression platforms (bacterial, yeast, plant, and mammalian cells). Computational molecular engineering and molecular informatics‐guided protein engineering together with experimental evolution will be used in modifying existing enzymatic activities and designing enzymes with new activities. Biological engineering for the production of biological molecules will be combined with organic synthesis where needed. This approach is expected to provide streamlined green chemistry solutions for chemical production.