CEMCE publications 2018

1. Lulla, V., Karo-Astover, L., Rausalu, K., Saul, S., Merits, A. and Lulla, A. (2018) Timeliness of proteolytic events is prerequisite for efficient functioning of the alphaviral replicase. Journal of Virology, pii: JVI.00151-18. doi: 10.1128/JVI.00151-18.

2. Bartholomeeusen, K., Utt, A., Coppens, S., Rausalu, K., Vereecken, K., Ariën, K.K. and Merits, A. (2018). A Chikungunya virus trans-replicase system reveals the importance of delayed non-structural polyprotein processing for efficient replication complex formation in mosquito cells. Journal of Virology, pii: JVI.00152-18. doi: 10.1128/JVI.00152-18.

3. Mutso, M., Morro, A.M., Smedberg, C., Kasvandik, S., Aquilimeba, M., Teppor, M., Tarve, L., Lulla, A., Lulla, V., Saul, S., Thaa, B., McInerney, G.M., Merits, A. and Varjak, M. (2018). Mutation of CD2AP and SH3KBP1 binding motif in alphavirus nsP3 hypervariable domain results in attenuated virus. Viruses. 10(5). pii: E226. doi: 10.3390/v10050226.

4. Abraham, R., Hauer, D., McPherson R.L., Utt, A., Kirby, I.,  Cohen, M.S., Merits, A, Leung, A.K.L. and Griffin, D.E. (2018) ADP ribosyl-binding and hydrolase activities of the alphavirus nsP3 macrodomain are critical for initiation of virus replication. Proceedings of the National Academy of Sciences of the U S A, pii: 201812130. doi: 10.1073/pnas.1812130115

5. Oo, A., Rausalu, K., Merits, A., Higgs, S., Vanlandingham, D., Abu Bakar, S. and Zandi, K. (2018). Deciphering the potential of baicalin as an antiviral agent for Chikungunya virus infection. Antiviral Research, 150:101-111. doi: 10.1016/j.antiviral.2017.12.012

6. Varjak, M., Dietrich, I., Sreenu, V.B., Till, B.E., Merits, A., Kohl, A. and Schnettler, E. (2018) Spindle-E acts antivirally against alphaviruses in mosquito cells. Viruses. 10(2). pii: E88. doi: 10.3390/v10020088.

7. Ianevski, A., Zusinaite, E., Kuivanen, S., Strand, M., Lysvand, H., Teppor, M., Kakkola, L., Paavilainen, H., Laajala, M., Kallio-Kokko, H., Valkonen, M., Kantele, A., Telling, K., Lutsar, I., Letjuka, P., Metelitsa, N., Oksenych, V., Bjørås, M., Nordbø, S.A., Dumpis, U., Vitkauskiene, A., Öhrmalm, C., Bondeson, K., Bergqvist, A., Aittokallio, T., Cox, R.J., Evander, M., Hukkanen, V., Marjomaki, V., Julkunen, I., Vapalahti, O., Tenson, T., Merits, A. and Kainov D. (2018) Novel activities of safe-in-human broad-spectrum antiviral agents. Antiviral Research, 154, 174-182. doi: 10.1016/j.antiviral.2018.04.016.

8. Liu, X., Mutso, M., Utt, A., Lepland, A., Herrero, L., Taylor, A., Bettadapura, J., Rudd, P., Merits, A. and Mahalingam, S. (2018). Decreased virulence of Ross River virus harboring mutation in the first cleavage site of non-structural polyprotein is caused by a novel mechanism leading to increased production of interferon-inducing RNAs”. mBio, 9(4). pii: e00044-18. doi: 10.1128/mBio.00044-18.

9. Remenyi, R., Gao, Y., Hughes, R., Curd, A., Zothner, C., Peckham, M., Merits, A. and Harris, M. (2018). Persistent replication of a chikungunya virus replicon in human cells is associated with presence of stable cytoplasmic granules containing non-structural protein 3. Journal of Virology, 92, pii: e00477-18. doi: 10.1128/JVI.00477-18

10. Öhlund, P., García-Arriaza, J., Žusinaite, E., Szurgot, I., Männik, A., Kraus, A., Ustav, M., Merits, A., Esteban, M., Liljeström, P. and Ljungberg, K. (2018). DNA-launched RNA replicon vaccines induce potent anti-Ebolavirus immune responses that can be further improved by a recombinant MVA boost. Scientific Reports, 8(1):12459. doi: 10.1038/s41598-018-31003-6.

11. Meutiawati, F.,  Bezemer, B.,  Strating, J.R.P.M,  Overheul, G.J., Žusinaite, E., van Kuppeveld, F.J.M.,  van Cleef, K.W.R. and van Rij, R.P. (2018) Posaconazole inhibits dengue virus replication by targeting oxysterol-binding protein. Antiviral Research, 157:68-79. doi: 10.1016/j.antiviral.2018.06.017.

12. Matkovic, R., Bernard, E., Fontanel, S., Eldin, P., Chazal, N., Hassan Hersi, D., Merits, A., Péloponèse, J.M.Jr. and Briant, L. (2018) The host DHX9 DExH Box helicase is recruited to Chikungunya virus replication complexes for optimal genomic RNA translation. Journal of Virology. pii: JVI.01764-18. doi: 10.1128/JVI.01764-18.

13. Õunap, K.; Kurg, K.; Võsa, L.; Maiväli, Ü.; Teras, M.; Planken, A.; Ustav, M; Kurg, R. (2018). Antibody response against cancer‑testis antigens MAGEA4 and MAGEA10 in patients with melanoma. Oncology Letters, 16 (1), 211−2018.10.3892/ol.2018.8684.

14. Podgórska M, Ołdak M, Marthaler A, Fingerle A, Walch-Rückheim B, Lohse S, Müller CSL, Vogt T, Ustav M, Wnorowski A, Malejczyk M, Majewski S, Smola S.Chronic Inflammatory Microenvironment in Epidermodysplasia Verruciformis Skin Lesions: Role of the Synergism Between HPV8 E2 and C/EBPβ to Induce Pro-Inflammatory S100A8/A9 Proteins.  Front Microbiol. 2018 Mar 7;9:392. doi: 10.3389/fmicb.2018.00392. eCollection 2018.

15. Lázaro-Frías A, Gómez-Medina S, Sánchez-Sampedro L, Ljungberg K, Ustav M, Liljeström P, Muñoz-Fontela C, Esteban M, García-Arriaza J.  Distinct Immunogenicity and Efficacy of Poxvirus-Based Vaccine Candidates against Ebola Virus Expressing GP and VP40 Proteins. J Virol. 2018 May 14;92(11). pii: e00363-18. doi: 10.1128/JVI.00363-18. Print 2018 Jun 1.

16. Sankovski E, Abroi A, Ustav M Jr, Ustav M. Nuclear myosin 1 associates with papillomavirus E2 regulatory protein and influences viral replication. Virology. 2018 Jan 15;514:142-155. doi: 10.1016/j.virol.2017.11.013. Epub 2018 Jan 4.

17. Kasak L, Näks M, Eek P, Piirsoo A, Bhadoria R, Starkov P, Saarma M, Kasvandik S, Piirsoo M. Characterization of Protein Kinase ULK3 Regulation by Phosphorylation and Inhibition by Small Molecule SU6668. Biochemistry. 2018 Sep 18;57(37):5456-5465. doi: 10.1021/acs.biochem.8b00356. Epub 2018 Sep 4.

18. Ivanova, L.; Tammiku-Taul, J.; Sidorova, Y.; Saarma, M., Karelson, M. Small-Molecule Ligands as Potential GDNF Family Receptor Agonists, ACS Omega. 2018, 3, 1022-1030. DOI: 10.1021/acsomega.7b01932.

19. Ivanova, L.; Karelson, M.; Dobchev, D.A. Identification of Natural Compounds against Neurodegenerative Diseases Using In Silico Techniques, MOLECULES, 2018, 23, Article Number: 1847. DOI: 10.3390/molecules23081847.

20. Ivanova, L.; Tammiku-Taul, J.; Garcia-Sosa, A.T.; Sidorova, Y.; Saarma, M., Karelson, M. Molecular Dynamics Simulations of the Interactions between Glial Cell Line-Derived Neurotrophic Factor Family Receptor GFR alpha 1 and Small-Molecule Ligands, ACS Omega. 2018, 3, 11407-11414. DOI: 10.1021/acsomega.8b01524.

21. Oja, M.; Maran, U. pH-permeability profiles for drug substances: Experimental detection, comparison with human intestinal absorption and modelling, Eur. J. Pharm. Sci. 2018, 123, 429-440. DOI:10.1016/j.ejps.2018.07.014.

22. Piir, G.; Kahn, I.; García-Sosa, A. T.; Sild, S.; Ahte, P.; Maran, U. Best practices for QSAR model reporting: Physical and chemical properties, ecotoxicity, environmental fate, human health and toxicokinetics endpoints. Environ. Health Perspect. 2018, In press. DOI: 10.1289/EHP3264.

23. Murina V, Kasari M, Takada H, Hinnu M, Saha CK, Grimshaw JW, Seki T, Reith M, Putrinš M, Tenson T, Strahl H, Hauryliuk V, Atkinson GC. (2018). ABCF ATPases Involved in Protein Synthesis, Ribosome Assembly and Antibiotic Resistance: Structural and Functional Diversification across the Tree of Life. J Mol Biol. 2018 Dec 28. pii: S0022-2836(18)31288-9. doi: 10.1016/j.jmb.2018.12.013. [Epub ahead of print]

24. Aun E, Brauer A, Kisand V, Tenson T, Remm M. (2018). A k-mer-based method for the identification of phenotype-associated genomic biomarkers and predicting phenotypes of sequenced bacteria. PLoS Comput Biol. 2018 Oct 22;14(10):e1006434. doi: 10.1371/journal.pcbi.1006434.

25. Mets T, Kasvandik S, Saarma M, Maiväli Ü, Tenson T, Kaldalu N. (2019, E-publication 2018) Fragmentation of Escherichia coli mRNA by MazF and MqsR.Biochimie. 2019 Jan;156:79-91. doi: 10.1016/j.biochi.2018.10.004. Epub 2018 Oct 10.

26. Telling K, Laht M, Brauer A, Remm M, Kisand V, Maimets M, Tenson T, Lutsar I. (2018). Multidrug resistant Pseudomonas aeruginosa in Estonian hospitals BMC Infect Dis. 2018 Oct 11;18(1):513. doi: 10.1186/s12879-018-3421-1.

27. Zusinaite E, Ianevski A, Niukkanen D, Poranen MM, Bjørås M, Afset JE, Tenson T, Velagapudi V, Merits A, Kainov DE. A Systems Approach to Study Immuno- and Neuro-Modulatory Properties of Antiviral Agents. (2018). Viruses. 2018 Aug 12;10(8). pii: E423. doi: 10.3390/v10080423. Review.

28. Zupančič Š, Preem L, Kristl J, Putrinš M, Tenson T, Kocbek P, Kogermann K.(2018). Impact of PCL nanofiber mat structural properties on hydrophilic drug release and antibacterial activity on periodontal pathogens. Eur J Pharm Sci. 2018 Sep 15;122:347-358. doi: 10.1016/j.ejps.2018.07.024. Epub 2018 Jul 12.

29. Goormaghtigh F, Fraikin N, Putrinš M, Hauryliuk V, Garcia-Pino A, Udekwu K, Tenson T, Kaldalu N, Van Melderen L. (2018). Reply to Holden and Errington, “Type II Toxin-Antitoxin Systems and Persister Cells”. MBio. 2018 Sep 25;9(5). pii: e01838-18. doi: 10.1128/mBio.01838-18.

30. Goormaghtigh F, Fraikin N, Putrinš M, Hallaert T, Hauryliuk V, Garcia-Pino A, Sjödin A, Kasvandik S, Udekwu K, Tenson T, Kaldalu N, Van Melderen L. (2018). Reassessing the Role of Type II Toxin-Antitoxin Systems in Formation of Escherichia coli Type II Persister Cells. MBio. 2018 Jun 12;9(3). pii: e00640-18. doi: 10.1128/mBio.00640-18.

31. Ianevski A, Zusinaite E, Kuivanen S, Strand M, Lysvand H, Teppor M, Kakkola L, Paavilainen H, Laajala M, Kallio-Kokko H, Valkonen M, Kantele A, Telling K, Lutsar I, Letjuka P, Metelitsa N, Oksenych V, Bjørås M, Nordbø SA, Dumpis U, Vitkauskiene A, Öhrmalm C, Bondeson K, Bergqvist A, Aittokallio T, Cox RJ, Evander M, Hukkanen V, Marjomaki V, Julkunen I, Vapalahti O, Tenson T, Merits A, Kainov D. (2018). Novel activities of safe-in-human broad-spectrum antiviral agents. Antiviral Res. 2018 Jun;154:174-182. doi: 10.1016/j.antiviral.2018.04.016. Epub 2018 Apr 23.

32. Kudrin P, Dzhygyr I, Ishiguro K, Beljantseva J, Maksimova E, Oliveira SRA, Varik V, Payoe R, Konevega AL, Tenson T, Suzuki T, Hauryliuk V. (2018). The ribosomal A-site finger is crucial for binding and activation of the stringent factor RelA. Nucleic Acids Res. 2018 Feb 28;46(4):1973-1983. doi: 10.1093/nar/gky023.

33. Manav MC, Beljantseva J, Bojer MS, Tenson T, Ingmer H, Hauryliuk V, Brodersen DE. (2018). Structural basis for (p)ppGpp synthesis by the Staphylococcus aureus small alarmone synthetase RelP. J Biol Chem. 2018 Mar 2;293(9):3254-3264. doi: 10.1074/jbc.RA117.001374. Epub 2018 Jan 11.

34. Lopušanskaja, E.; Paju, A.; Järving, I.; Lopp, M. (2018). Synthesis of Cyclic 3-Aryl-Substituted 1,2-Dicarbonyl Compounds via Suzuki Cross-Coupling Reactions. Synthesis, 50 (9), 1883-1890. 10.1055/s-0036-1591543.

35. Maljutenko, K.; Borovkov, V.; Kananovich, D.; Järving, I.; Lopp, M. (2018). Aerobic cascade oxidation of substituted cyclopentane-1,2-diones using metalloporphyrin catalysts. Tetrahedron, 74 (6), 661-664. 10.1016/j.tet.2017.12.009.

36. Reitel, K.; Kadri Kriis, K.; Järving, I.; Kanger, T. (2018). Study of the asymmetric organocatalyzed [3+2] annulation of cyclopropenone and β-keto ester. Khimiya Geterotsiklicheskikh Soedinenii,54(10), 929-933. 10.1007/s10593-018-2372-1.

37. Trubitsõn, D.; Žari, S.; Kaabel, S.; Kudrjashova, M.; Kriis, K.; Järving, I.; Pehk, T.; Kanger, T. (2018). Asymmetric Organocatalytic Cascade Synthesis of Tetrahydrofuranyl Spirooxindoles. Synthesis, 50 (02), 314−322. 10.1055/s-0036-1590918.

38. Aav, R.; Mishra, K. A. (2018). The Breaking of Symmetry Leads to Chirality in Cucurbituril-Type Hosts. Symmetry, 10 (4), 98.10.3390/sym10040098.

39. Adamson, J.; Nazarski, R. B.; Jarvet, J.; Pehk, T.; Aav, R. (2018). Shortfall of B3LYP in Reproducing NMR JCH Couplings in Some Isomeric Epoxy Structures with Strong Stereoelectronic Effects: A Benchmark Study on DFT Functionals. ChemPhysChem. 10.1002/cphc.201701125.

40. Aid, T.; Koel, M.; Lopp, M.; Vaher, M. (2018). Metal-Catalyzed Degradation of Cellulose in Ionic Liquid Media. Inorganics, 78 (6), 1-11. 10.3390/inorganics6030078.

41. Kaabel, S.; Aav, R. (2018). Templating Effects in the Dynamic Chemistry of Cucurbiturils and Hemicucurbiturils. Israel Journal of Chemistry, 58 (3-4), 296-313. 10.1002/ijch.201700106.

42. Peterson, A.; Kaabel, S.; Kahn, I.; Pehk, T.; Aav, R.; Adamson, J.; (2018). Unsubstituted Oxacalix[n]arenes (n=4 and 8): A Conformational Study in Solution and Solid State and Interaction Studies with Aromatic Guests. ChemistrySelect, 3, 9091-9095. slct.201801590.

43. Merilo, E; Yarmolinsky, D; Jalakas, P; Parik, H; Tulva, I; Rasulov, B; Kilk, K; Kollist, H. 2018. Stomatal VPD response: there is more to the story than ABA. Plant Physiology, 176: 851−864.http://www.plantphysiol.org/content/plantphysiol/176/1/851.full.pdf

44. Jalakas, P; Tulva, I; Kangor, T; Sooväli, P; Rasulov, B; Tamm, Ü; Koppel, M; Kollist, H; Merilo, E. 2018. Gas exchange-yield relationships of malting barley genotypes treated with fungicides and biostimulants. European Journal of Agronomy, 99: 129−137.https://www.sciencedirect.com/science/article/pii/S1161030118302703?via%3Dihub

45. Hsu, P-K; Takahashi, Y; Munemasa, S; Merilo, E; Laanemets, K; Waadt, R; Pater, D; Kollist, H; Schroeder, J. I. 2018. Abscisic acid-independent stomatal CO2 signal transduction pathway and convergence of CO2 and ABA signaling downstream of OST1 kinase. PNAS, 115:  E9971-E9980. https://www.pnas.org/content/pnas/115/42/E9971.full.pdf

46. Overmyer, K; Vuorinen, K; Brosché, M. 2018. Interaction points in plant stress signaling pathways. Physiologia Plantarum, 162: 191–204.https://onlinelibrary.wiley.com/doi/full/10.1111/ppl.12639

47. Gutermuth, T; Herbell, S; Lassig, R; Brosché, M; Romeis, T; Feijo, JA; Hedrich, R; Konrad KR. 2018. Tip‐localized Ca2+‐permeable channels control pollen tube growth via kinase‐dependent R‐ and S‐type anion channel regulation. New Phytologist, 218: 1089–1105. https://doi.org/10.1111/nph.15067

48. Jalakas, P; Merilo, E; Kollist, H; Brosché, M. 2018. ABA‐mediated regulation of stomatal density is OST1‐independent. Plant Direct, 9: 1-7. https://doi.org/10.1002/pld3.82

49. Tõldsepp, K; Zhang, J; Takahashi, Y; Sindarovska, Y; Hõrak, H; Ceciliato, P; Koolmeister, K; Wang, Y-S; Vaahtera, L; Jakobson, L; Yeh, C-Y; Park, J; Brosche, MJ; Kollist, H; Schroeder, J. 2018. Mitogen‐activated protein kinases MPK4 and MPK12 are key components mediating CO2‐induced stomatal movements. Plant Journal, 96: 1018-1035.https://onlinelibrary.wiley.com/doi/full/10.1111/tpj.14087

50. Zhang J, De-oliveira-Ceciliato, P; Takahashi, Y; Schulze S; Dubeaux, G; Hauser F; Azoulay-Shemer, T; Tõldsepp, K; Kollist, H; Rappel, W-J; Schroeder, JI. 2018. Insights into the Molecular Mechanisms of CO2-Mediated Regulation of Stomatal Movements. Current Biology 28: 1356-363.https://www.sciencedirect.com/science/article/pii/S0960982218313447?via%3Dihub

51. Sierla, M; Hõrak, H;  Overmyer, K; Waszczak, C; Yarmolinsky, D; Maierhofer, T; Vainonen, JP; Salojärvi, J; Denessiouk, K; Laanemets, K; Tõldsepp, K; Vahisalu, T; Gauthier, A; Puukko, T; Paulin, L; Auvinen, P; Geiger, D; Hedrich, R; Kollist, H; Kangasjärvi, J. 2018. The Receptor-like Pseudokinase GHR1 Is Required for Stomatal Closure. Plant Cell, 30: 2813-2837. http://www.plantcell.org/content/30/11/2813

52. Ehonen, S; Yarmolinsky, D; Kollist, H; Kangasjärvi, J. 2018. Reactive Oxygen Species, Photosynthesis, and Environment in the Regulation of Stomata. Antioxidants & Redox Signalinghttps://www.liebertpub.com/doi/10.1089/ars.2017.7455

53. Rasulov, B; Talts, E; Bichele, I; Niinemets, Ü. 2018. Evidence that isoprene emission is not limited by cytosolic metabolites. Exogenous malate does not invert the reverse sensitivity of isoprene emission to high [CO2]. Plant Physiology, 176: 1573−1586. http://www.plantphysiol.org/content/176/2/1573

54. de Souza, V F; Niinemets, Ü; Rasulov, B; Vickers, CE; Duvoisin Júnior, S; Araújo, W L; de Carvalho Gonçalves, JF. 2018. Alternative carbon sources for isoprene emission. Trends in Plant Science, 23, 1081−1101.https://www.sciencedirect.com/science/article/pii/S1360138518302176?via%3Dihub

55. Hangas, A; Aasumets, K; Kekäläinen, NJ; Paloheinä, M; Pohjoismäki, JL; Gerhold, JM; Goffart, S. 2018. Ciprofloxacin impairs mitochondrial DNA replication initiation through inhibition of Topoisomerase 2. Nucleic Acids Research.10.1093/nar/gky793.https://academic.oup.com/nar/article/46/18/9625/5088042

56. Pandey, AK;  Ghosh, A; Agrawal, M; Agrawal, SB. 2018. Effect of elevated ozone and varying levels of soil nitrogen in two wheat (Triticum aestivum L.) cultivars: Growth, gas-exchange, antioxidant status, grain yield and quality. Ecotoxicology and Environmental Safety 158: 59-68 https://www.sciencedirect.com/science/article/pii/S0147651318303099

57. Künnapuu K, Veiman KL, Porosk L, Rammul E, Kiisholts K, Langel Ü, Kurrikoff K. Tumor gene therapy by systemic delivery of plasmid DNA with cell‐penetrating peptides.  FASEB BioAdvances. 2018;1–10.

58. Freimann K, Arukuusk P, Kurrikoff K, Pärnaste L, Raid R, Piirsoo A, Pooga M, Langel Ü. Formulation of Stable and Homogeneous Cell-Penetrating Peptide NF55 Nanoparticles for Efficient Gene Delivery In Vivo. Mol Ther Nucleic Acids. 2018 Mar 2;10:28-35. doi: 10.1016/j.omtn.2017.10.011. Epub 2017 Oct 20. PMID: 29499941

59. Cerrato,C.P., and Langel,Ü. Cell-penetrating peptides targeting mitochondria. In : P.J.Oliveira (ed.), Mitochondrial Biology and Experimental Therapeutics. (2018) Springer, pp. 593-611.

60. Alvarez MJ, Subramaniam PS, Tang LH, Grunn A, Aburi M, Rieckhof G, Komissarova EV, Hagan EA, Bodei L, Clemons PA, Dela Cruz FS, Dhall D, Diolaiti D, Fraker DA, Ghavami A, Kaemmerer D, Karan C, Kidd M, Kim KM, Kim HC, Kunju LP, Langel Ü, Li Z, Lee J, Li H, LiVolsi V, Pfragner R, Rainey AR, Realubit RB, Remotti H, Regberg J, Roses R, Rustgi A, Sepulveda AR, Serra S, Shi C, Yuan X, Barberis M, Bergamaschi R, Chinnaiyan AM, Detre T, Ezzat S, Frilling A, Hommann M, Jaeger D, Kim MK, Knudsen BS, Kung AL, Leahy E, Metz DC, Milsom JW, Park YS, Reidy-Lagunes D, Schreiber S, Washington K, Wiedenmann B, Modlin I, Califano A. A precision oncology approach to the pharmacological targeting of mechanistic dependencies in neuroendocrine tumors. Nat Genet. 2018 Jul;50(7):979-989. doi: 10.1038/s41588-018-0138-4. Epub 2018 Jun 18. PMID: 29915428

61. Srimanee A, Arvanitidou M, Kim K, Hällbrink M, Langel Ü. Cell-penetrating peptides for siRNA delivery to glioblastomas. Peptides. 2018 Apr 22;104:62-69. doi:  10.1016/j.peptides.2018.04.015. [Epub ahead of print] PMID: 29684592

62. Lorents A, Säälik P, Langel Ü, Pooga M. Arginine-Rich Cell-Penetrating Peptides Require Nucleolin and Cholesterol-Poor Subdomains for Translocation across Membranes. Bioconjug Chem. 2018 Apr 18;29(4):1168-1177. doi: 10.1021/acs.bioconjchem.7b00805. Epub 2018 Mar 14. PMID: 29510042

63. Vasconcelos L, Lehto T, Madani F, Radoi V, Hällbrink M, Vukojević V, Langel Ü.Simultaneous membrane interaction of amphipathic peptide monomers, self-aggregates and cargo complexes detected by fluorescence correlation spectroscopy. Biochim Biophys Acta. 2018 Feb;1860(2):491-504. doi: 10.1016/j.bbamem.2017.09.024. Epub 2017 Sep 28. PMID: 28962904