New Publication: single-cell profiling of splenic immune ageing and chronic stress adaptations in mice with natural microbiota

Members of our UTARTU lab have recently published a new research article titled “Single-cell profiling of splenic immune ageing and chronic stress adaptations in mice with natural microbiota.”

In this study, the team investigated how the immune system changes with age by profiling spleen immune cells from young and old mice using single-cell RNA sequencing. The analysis revealed several key features of immune aging, including shifts in immune cell function, increased inflammatory signals, and signs of cellular exhaustion. To place these findings into a broader context, the researchers also integrated their data with several previously published datasets, creating a atlas of more than 270,000 splenic immune cells. This resource provides a valuable foundation for future studies exploring how aging affects immune responses.

To learn more you can find the full article here: https://onlinelibrary.wiley.com/doi/10.1002/eji.70170