Study Group of Translational Neuropsychiatry

Eero Vasar Research Group

The Vasar Laboratory focuses on translational neuropsychiatric research using a genetically defined mouse model with Negr1 deficiency. This model exhibits susceptibility to behavioral alterations and brain endophenotypes relevant to psychiatric disorders, alongside increased vulnerability to metabolic disturbances.

Our research aims to elucidate biological mechanisms linking neuropsychiatric and metabolic phenotypes. Using complementary behavioral, molecular, and pharmacological approaches, we investigate how these phenotypes emerge in the Negr1-deficient model and identify molecular pathways through which genetic and pharmacological factors exert their effects. As part of this work, we also examine the long-term metabolic consequences of chronic antipsychotic treatment.

Alongside preclinical studies, the Vasar Laboratory conducts parallel research in human cohorts. By integrating findings from animal models with human data, our work contributes to a better understanding of disease- and treatment-related mechanisms in severe mental disorders and supports the development of more informed and individualized diagnostic and therapeutic approaches.