{"id":348,"date":"2025-12-08T13:15:59","date_gmt":"2025-12-08T11:15:59","guid":{"rendered":"https:\/\/sisu.ut.ee\/sysage\/?page_id=348"},"modified":"2026-01-23T11:57:37","modified_gmt":"2026-01-23T09:57:37","slug":"why-do-we-age-molecular-and-cellular-mechanisms-of-aging","status":"publish","type":"page","link":"https:\/\/sisu.ut.ee\/sysage\/why-do-we-age-molecular-and-cellular-mechanisms-of-aging\/","title":{"rendered":"T-cell Aging"},"content":{"rendered":"<figure class=\"wp-block-image aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1414\" height=\"316\" src=\"https:\/\/sisu.ut.ee\/wp-content\/uploads\/sites\/784\/Courses_title.png\" alt=\"\" class=\"wp-image-384\" srcset=\"https:\/\/sisu.ut.ee\/wp-content\/uploads\/sites\/784\/Courses_title.png 1414w, https:\/\/sisu.ut.ee\/wp-content\/uploads\/sites\/784\/Courses_title-300x67.png 300w, https:\/\/sisu.ut.ee\/wp-content\/uploads\/sites\/784\/Courses_title-1024x229.png 1024w, https:\/\/sisu.ut.ee\/wp-content\/uploads\/sites\/784\/Courses_title-768x172.png 768w\" sizes=\"auto, (max-width: 1414px) 100vw, 1414px\"><\/figure>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-center\">Why Do We Age? \u2013 Molecular and Cellular Mechanisms of Aging<\/h2>\n\n\n\n<p>This page collects the lecture slides from the PhD course <em>Why Do We Age? \u2013 Molecular and Cellular Mechanisms of Aging<\/em>, held at University Copenhagen on 01\u201303.09.2025. The course combines molecular and cellular biology, immunology and clinical medicine to explore how aging affects cells, organs and whole organisms, and how this leads to multimorbidity and age-related disease.<\/p>\n\n\n\n<p>The resources below follow the structure of the course programme and can be used for preparation, revision or as references for your own projects on aging.<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Molecular models of aging <\/h2>\n\n\n\n<p>By Claus Desler Madsen                                                        <\/p>\n\n\n\n<div data-wp-interactive=\"core\/file\" class=\"wp-block-file\"><object data-wp-bind--hidden=\"!state.hasPdfPreview\" hidden class=\"wp-block-file__embed\" data=\"https:\/\/sisu.ut.ee\/wp-content\/uploads\/sites\/784\/WDWA_Molecular_Models_of_Aging_Claus_D_Madsen_-20250901.pdf\" type=\"application\/pdf\" style=\"width:100%;height:450px\" aria-label=\"Embed of WDWA_Molecular_Models_of_Aging_Claus_D_Madsen_ 20250901.\"><\/object><a id=\"wp-block-file--media-58d5c46d-a5cc-4577-bf1b-64e6dfa09381\" href=\"https:\/\/sisu.ut.ee\/wp-content\/uploads\/sites\/784\/WDWA_Molecular_Models_of_Aging_Claus_D_Madsen_-20250901.pdf\">WDWA_Molecular_Models_of_Aging_Claus_D_Madsen_ 20250901<\/a><a href=\"https:\/\/sisu.ut.ee\/wp-content\/uploads\/sites\/784\/WDWA_Molecular_Models_of_Aging_Claus_D_Madsen_-20250901.pdf\" class=\"wp-block-file__button wp-element-button\" download aria-describedby=\"wp-block-file--media-58d5c46d-a5cc-4577-bf1b-64e6dfa09381\">Download<\/a><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading\">Genetic Ghosts: The Dark Genomes Reawakening During Aging <\/h2>\n\n\n\n<p>By Kaare V. Grunddal<\/p>\n\n\n\n<div data-wp-interactive=\"core\/file\" class=\"wp-block-file\"><object data-wp-bind--hidden=\"!state.hasPdfPreview\" hidden class=\"wp-block-file__embed\" data=\"https:\/\/sisu.ut.ee\/wp-content\/uploads\/sites\/784\/WDWA_Genetic_Ghosts_Kaare_V_Grunddal_2025-09-02.pdf\" type=\"application\/pdf\" style=\"width:100%;height:460px\" aria-label=\"Embed of WDWA_Genetic_Ghosts_Kaare_V_Grunddal_2025-09-02.\"><\/object><a id=\"wp-block-file--media-7cd83cf9-231f-4957-82ad-354b90b8a075\" href=\"https:\/\/sisu.ut.ee\/wp-content\/uploads\/sites\/784\/WDWA_Genetic_Ghosts_Kaare_V_Grunddal_2025-09-02.pdf\">WDWA_Genetic_Ghosts_Kaare_V_Grunddal_2025-09-02<\/a><a href=\"https:\/\/sisu.ut.ee\/wp-content\/uploads\/sites\/784\/WDWA_Genetic_Ghosts_Kaare_V_Grunddal_2025-09-02.pdf\" class=\"wp-block-file__button wp-element-button\" download aria-describedby=\"wp-block-file--media-7cd83cf9-231f-4957-82ad-354b90b8a075\">Download<\/a><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading\">The challenge of appropriate medication<br>prescribing for older adults <\/h2>\n\n\n\n<p>By Morten Baltzer Houlind<\/p>\n\n\n\n<div data-wp-interactive=\"core\/file\" class=\"wp-block-file\"><object data-wp-bind--hidden=\"!state.hasPdfPreview\" hidden class=\"wp-block-file__embed\" data=\"https:\/\/sisu.ut.ee\/wp-content\/uploads\/sites\/784\/WDWA_The_challenge_of_appropriate_medication_perscribing_for_older_adults_Morten_Baltzer_Houlind_010925.pdf\" type=\"application\/pdf\" style=\"width:100%;height:480px\" aria-label=\"Embed of WDWA_The_challenge_of_appropriate_medication_perscribing_for_older_adults_Morten_Baltzer_Houlind_010925.\"><\/object><a id=\"wp-block-file--media-e91f280f-e5aa-4291-bcb7-2d970240f0ce\" href=\"https:\/\/sisu.ut.ee\/wp-content\/uploads\/sites\/784\/WDWA_The_challenge_of_appropriate_medication_perscribing_for_older_adults_Morten_Baltzer_Houlind_010925.pdf\">WDWA_The_challenge_of_appropriate_medication_perscribing_for_older_adults_Morten_Baltzer_Houlind_010925<\/a><a href=\"https:\/\/sisu.ut.ee\/wp-content\/uploads\/sites\/784\/WDWA_The_challenge_of_appropriate_medication_perscribing_for_older_adults_Morten_Baltzer_Houlind_010925.pdf\" class=\"wp-block-file__button wp-element-button\" download aria-describedby=\"wp-block-file--media-e91f280f-e5aa-4291-bcb7-2d970240f0ce\">Download<\/a><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading\">Power &amp; Balance:<br>Mitochondrial Homeostasis in Aging <\/h2>\n\n\n\n<p>By Fabian Finger<\/p>\n\n\n\n<div data-wp-interactive=\"core\/file\" class=\"wp-block-file\"><object data-wp-bind--hidden=\"!state.hasPdfPreview\" hidden class=\"wp-block-file__embed\" data=\"https:\/\/sisu.ut.ee\/wp-content\/uploads\/sites\/784\/WDWA_Mitochondrial_Homeostasis_in_aging_Fabian_Finger_20250902.pdf\" type=\"application\/pdf\" style=\"width:100%;height:480px\" aria-label=\"Embed of WDWA_Mitochondrial_Homeostasis_in_aging_Fabian_Finger_20250902.\"><\/object><a id=\"wp-block-file--media-b89cb351-d4bf-4417-9773-6ee0d9aa7a0f\" href=\"https:\/\/sisu.ut.ee\/wp-content\/uploads\/sites\/784\/WDWA_Mitochondrial_Homeostasis_in_aging_Fabian_Finger_20250902.pdf\">WDWA_Mitochondrial_Homeostasis_in_aging_Fabian_Finger_20250902<\/a><a href=\"https:\/\/sisu.ut.ee\/wp-content\/uploads\/sites\/784\/WDWA_Mitochondrial_Homeostasis_in_aging_Fabian_Finger_20250902.pdf\" class=\"wp-block-file__button wp-element-button\" download aria-describedby=\"wp-block-file--media-b89cb351-d4bf-4417-9773-6ee0d9aa7a0f\">Download<\/a><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Terminal Heart Failure<\/h2>\n\n\n\n<p>By Helena Dom\u00ednguez<\/p>\n\n\n\n<div data-wp-interactive=\"core\/file\" class=\"wp-block-file\"><object data-wp-bind--hidden=\"!state.hasPdfPreview\" hidden class=\"wp-block-file__embed\" data=\"https:\/\/sisu.ut.ee\/wp-content\/uploads\/sites\/784\/WDWA_Terminal_Heart_Failure_Helena_Dominguez_20250903.pdf\" type=\"application\/pdf\" style=\"width:100%;height:370px\" aria-label=\"Embed of WDWA_Terminal_Heart_Failure_Helena_Dominguez_20250903.\"><\/object><a id=\"wp-block-file--media-3c8a078f-e3fe-4874-94ae-7c4ecd455f65\" href=\"https:\/\/sisu.ut.ee\/wp-content\/uploads\/sites\/784\/WDWA_Terminal_Heart_Failure_Helena_Dominguez_20250903.pdf\">WDWA_Terminal_Heart_Failure_Helena_Dominguez_20250903<\/a><a href=\"https:\/\/sisu.ut.ee\/wp-content\/uploads\/sites\/784\/WDWA_Terminal_Heart_Failure_Helena_Dominguez_20250903.pdf\" class=\"wp-block-file__button wp-element-button\" download aria-describedby=\"wp-block-file--media-3c8a078f-e3fe-4874-94ae-7c4ecd455f65\">Download<\/a><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading\">Molecular and Clinical Perspectives on Multimorbidity in Elderly Patients<\/h2>\n\n\n\n<p>By Jon Amb\u00e6k Durhuus<\/p>\n\n\n\n<div data-wp-interactive=\"core\/file\" class=\"wp-block-file\"><object data-wp-bind--hidden=\"!state.hasPdfPreview\" hidden class=\"wp-block-file__embed\" data=\"https:\/\/sisu.ut.ee\/wp-content\/uploads\/sites\/784\/WDWA_Multimorbidity_in_Elderly_patients_Jon_A_Durhuus_20250903.pdf\" type=\"application\/pdf\" style=\"width:100%;height:380px\" aria-label=\"Embed of WDWA_Multimorbidity_in_Elderly_patients_Jon_A_Durhuus_20250903.\"><\/object><a id=\"wp-block-file--media-a5f21b3e-d8b7-4c20-91e7-611c78afd37f\" href=\"https:\/\/sisu.ut.ee\/wp-content\/uploads\/sites\/784\/WDWA_Multimorbidity_in_Elderly_patients_Jon_A_Durhuus_20250903.pdf\">WDWA_Multimorbidity_in_Elderly_patients_Jon_A_Durhuus_20250903<\/a><a href=\"https:\/\/sisu.ut.ee\/wp-content\/uploads\/sites\/784\/WDWA_Multimorbidity_in_Elderly_patients_Jon_A_Durhuus_20250903.pdf\" class=\"wp-block-file__button wp-element-button\" download aria-describedby=\"wp-block-file--media-a5f21b3e-d8b7-4c20-91e7-611c78afd37f\">Download<\/a><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading\">Innate Immune Sensing<br>in Aging: A double-edged sword<\/h2>\n\n\n\n<p>By Helena Borland Madsen<\/p>\n\n\n\n<div data-wp-interactive=\"core\/file\" class=\"wp-block-file\"><object data-wp-bind--hidden=\"!state.hasPdfPreview\" hidden class=\"wp-block-file__embed\" data=\"https:\/\/sisu.ut.ee\/wp-content\/uploads\/sites\/784\/WDWA_InnateImmunityInAging_Helena_B_Madsen_20250903.pdf\" type=\"application\/pdf\" style=\"width:100%;height:370px\" aria-label=\"Embed of WDWA_InnateImmunityInAging_Helena_B_Madsen_20250903.\"><\/object><a id=\"wp-block-file--media-662ad7d7-90d2-4d4f-93eb-93cc4c351ba3\" href=\"https:\/\/sisu.ut.ee\/wp-content\/uploads\/sites\/784\/WDWA_InnateImmunityInAging_Helena_B_Madsen_20250903.pdf\">WDWA_InnateImmunityInAging_Helena_B_Madsen_20250903<\/a><a href=\"https:\/\/sisu.ut.ee\/wp-content\/uploads\/sites\/784\/WDWA_InnateImmunityInAging_Helena_B_Madsen_20250903.pdf\" class=\"wp-block-file__button wp-element-button\" download aria-describedby=\"wp-block-file--media-662ad7d7-90d2-4d4f-93eb-93cc4c351ba3\">Download<\/a><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><h2 class=\"wp-block-post-title\">T-cell Aging<\/h2>\n\n\n<p>By P\u00e4rt Peterson<\/p>\n\n\n\n<div data-wp-interactive=\"core\/file\" class=\"wp-block-file\"><object data-wp-bind--hidden=\"!state.hasPdfPreview\" hidden class=\"wp-block-file__embed\" data=\"https:\/\/sisu.ut.ee\/wp-content\/uploads\/sites\/784\/WDWA_T_cell-aging__part_Peterson_20250903.pdf\" type=\"application\/pdf\" style=\"width:100%;height:370px\" aria-label=\"Embed of WDWA_T_cell aging__part_Peterson_20250903.\"><\/object><a id=\"wp-block-file--media-5622b686-b244-4abe-98e6-4ba5be67f5d0\" href=\"https:\/\/sisu.ut.ee\/wp-content\/uploads\/sites\/784\/WDWA_T_cell-aging__part_Peterson_20250903.pdf\">WDWA_T_cell aging__part_Peterson_20250903<\/a><a href=\"https:\/\/sisu.ut.ee\/wp-content\/uploads\/sites\/784\/WDWA_T_cell-aging__part_Peterson_20250903.pdf\" class=\"wp-block-file__button wp-element-button\" download aria-describedby=\"wp-block-file--media-5622b686-b244-4abe-98e6-4ba5be67f5d0\">Download<\/a><\/div>\n<\/div>\n<\/div>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Why Do We Age? \u2013 Molecular and Cellular Mechanisms of Aging This page collects the lecture slides from the PhD course Why Do We Age? \u2013 Molecular and Cellular Mechanisms of Aging, held at University Copenhagen on 01\u201303.09.2025. The course &#8230;<\/p>\n","protected":false},"author":605,"featured_media":384,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-348","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/sisu.ut.ee\/sysage\/wp-json\/wp\/v2\/pages\/348","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sisu.ut.ee\/sysage\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sisu.ut.ee\/sysage\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sisu.ut.ee\/sysage\/wp-json\/wp\/v2\/users\/605"}],"replies":[{"embeddable":true,"href":"https:\/\/sisu.ut.ee\/sysage\/wp-json\/wp\/v2\/comments?post=348"}],"version-history":[{"count":17,"href":"https:\/\/sisu.ut.ee\/sysage\/wp-json\/wp\/v2\/pages\/348\/revisions"}],"predecessor-version":[{"id":405,"href":"https:\/\/sisu.ut.ee\/sysage\/wp-json\/wp\/v2\/pages\/348\/revisions\/405"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sisu.ut.ee\/sysage\/wp-json\/wp\/v2\/media\/384"}],"wp:attachment":[{"href":"https:\/\/sisu.ut.ee\/sysage\/wp-json\/wp\/v2\/media?parent=348"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}