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The Vasar Laboratory focuses on translational neuropsychiatric research using a genetically defined mouse model with Negr1 deficiency. This model exhibits susceptibility to behavioral alterations and brain endophenotypes relevant to psychiatric disorders, alongside increased vulnerability to metabolic disturbances.<\/p>\n\n\n\n
Our research aims to elucidate biological mechanisms linking neuropsychiatric and metabolic phenotypes. Using complementary behavioral, molecular, and pharmacological approaches, we investigate how these phenotypes emerge in the Negr1-deficient model and identify molecular pathways through which genetic and pharmacological factors exert their effects. As part of this work, we also examine the long-term metabolic consequences of chronic antipsychotic treatment.<\/p>\n\n\n\n
Alongside preclinical studies, the Vasar Laboratory conducts parallel research in human cohorts. By integrating findings from animal models with human data, our work contributes to a better understanding of disease- and treatment-related mechanisms in severe mental disorders and supports the development of more informed and individualized diagnostic and therapeutic approaches.<\/p>\n\n\n\n