{"id":2671,"date":"2025-12-07T14:30:58","date_gmt":"2025-12-07T12:30:58","guid":{"rendered":"https:\/\/sisu.ut.ee\/ribolab\/?p=2671"},"modified":"2026-01-23T17:19:14","modified_gmt":"2026-01-23T15:19:14","slug":"translon-a-single-term-for-translated-regions","status":"publish","type":"post","link":"https:\/\/sisu.ut.ee\/ribolab\/translon-a-single-term-for-translated-regions\/","title":{"rendered":"Translon: a single term for translated regions"},"content":{"rendered":"

\u015awirski M. I, Baranov P et al<\/em>.<\/p>\n\n\n\n


We suggest using the term \u2018translon\u2019 (short for \u2018translated region\u2019), which has previously been introduced but failed to gain traction. It aligns well with other terms describing gene structures: intron (\u2018intragenic region\u2019) and exon (\u2018expressed region\u2019). Translon would fill the gap in the vocabulary used to describe units of genetic information. Unlike the existing terminology, translon is defined directly, by the process it aims to capture, instead of indirectly, through sequence or function. Most ORFs are not translons because they are not translated. All CDSs are translons, but not all translons are ORFs. We expect that the term translon will reduce confusion when discussing translated regions and will facilitate development of more biologically realistic annotations.<\/p>\n\n\n\n

Nat Methods. 2025 Oct;22(10):2002-2006. DOI: 10.1038\/s41592-025-02810-3.<\/a><\/p>\n\n\n\n

\"\"
Any nucleotide sequence can be represented as three sequences of nucleotide triplets (codons); that is, triplets read in three different reading frames. An ORF is defined as a sequence of sense codons bounded by a stop codon (purple bar) or from a start (most commonly ATG) to a stop (light blue bar). Below are examples of how different translated regions (translons) relate to ORFs.<\/figcaption><\/figure>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

\u015awirski M. I, Baranov P et al. We suggest using the term \u2018translon\u2019 (short for \u2018translated region\u2019), which has previously been introduced but failed to gain traction. It aligns well with other terms describing gene structures: intron (\u2018intragenic region\u2019) and …<\/p>\n","protected":false},"author":700,"featured_media":2672,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[11],"tags":[15],"class_list":["post-2671","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-artiklid","tag-artiklid"],"acf":[],"_links":{"self":[{"href":"https:\/\/sisu.ut.ee\/ribolab\/wp-json\/wp\/v2\/posts\/2671","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sisu.ut.ee\/ribolab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sisu.ut.ee\/ribolab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sisu.ut.ee\/ribolab\/wp-json\/wp\/v2\/users\/700"}],"replies":[{"embeddable":true,"href":"https:\/\/sisu.ut.ee\/ribolab\/wp-json\/wp\/v2\/comments?post=2671"}],"version-history":[{"count":3,"href":"https:\/\/sisu.ut.ee\/ribolab\/wp-json\/wp\/v2\/posts\/2671\/revisions"}],"predecessor-version":[{"id":2680,"href":"https:\/\/sisu.ut.ee\/ribolab\/wp-json\/wp\/v2\/posts\/2671\/revisions\/2680"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sisu.ut.ee\/ribolab\/wp-json\/wp\/v2\/media\/2672"}],"wp:attachment":[{"href":"https:\/\/sisu.ut.ee\/ribolab\/wp-json\/wp\/v2\/media?parent=2671"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sisu.ut.ee\/ribolab\/wp-json\/wp\/v2\/categories?post=2671"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sisu.ut.ee\/ribolab\/wp-json\/wp\/v2\/tags?post=2671"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}