{"id":1262,"date":"2018-01-24T12:00:00","date_gmt":"2018-01-24T10:00:00","guid":{"rendered":"https:\/\/sisu.ut.ee\/ribolab\/?p=1262"},"modified":"2024-10-23T11:58:02","modified_gmt":"2024-10-23T08:58:02","slug":"pseudouridine-free-escherichia-coli-ribosomes","status":"publish","type":"post","link":"https:\/\/sisu.ut.ee\/ribolab\/pseudouridine-free-escherichia-coli-ribosomes\/","title":{"rendered":"Pseudouridine-Free Escherichia coli Ribosomes"},"content":{"rendered":"<div class=\"wp-block-group is-layout-constrained wp-block-group-is-layout-constrained\">\n<p>O\u2019Connor M, Leppik M, Remme J.<\/p>\n\n\n\n<p>Pseudouridine (\u03a8) is present at conserved, functionally important regions in the ribosomal RNAs (rRNAs) from all three domains of life. Little, however, is known about the functions of \u03a8 modifications in bacterial ribosomes. An\u00a0<em>Escherichia coli<\/em>\u00a0strain has been constructed in which all seven rRNA \u03a8 synthases have been inactivated and whose ribosomes are devoid of all \u03a8s. Surprisingly, this strain displays only minor defects in ribosome biogenesis and function, and cell growth is only modestly affected. This is in contrast to a strong requirement for \u03a8 in eukaryotic ribosomes and suggests divergent roles for rRNA \u03a8 modifications in these two domains.<\/p>\n\n\n\n<p>J Bacteriol. 2018 Jan 24;200(4):e00540-17. doi: <a href=\"https:\/\/journals.asm.org\/doi\/10.1128\/jb.00540-17\" data-type=\"link\" data-id=\"https:\/\/journals.asm.org\/doi\/10.1128\/jb.00540-17\" target=\"_blank\" rel=\"noreferrer noopener\">10.1128\/JB.00540-17.<\/a><br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29180357\/\" data-type=\"link\" data-id=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29180357\/\" target=\"_blank\" rel=\"noreferrer noopener\">Pubmed<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>O\u2019Connor M, Leppik M, Remme J. Pseudouridine (\u03a8) is present at conserved, functionally important regions in the ribosomal RNAs (rRNAs) from all three domains of life. Little, however, is known about the functions of \u03a8 modifications in bacterial ribosomes. An\u00a0Escherichia &#8230;<\/p>\n","protected":false},"author":194,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[11],"tags":[],"class_list":["post-1262","post","type-post","status-publish","format-standard","hentry","category-artiklid"],"acf":[],"_links":{"self":[{"href":"https:\/\/sisu.ut.ee\/ribolab\/wp-json\/wp\/v2\/posts\/1262","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sisu.ut.ee\/ribolab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sisu.ut.ee\/ribolab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sisu.ut.ee\/ribolab\/wp-json\/wp\/v2\/users\/194"}],"replies":[{"embeddable":true,"href":"https:\/\/sisu.ut.ee\/ribolab\/wp-json\/wp\/v2\/comments?post=1262"}],"version-history":[{"count":1,"href":"https:\/\/sisu.ut.ee\/ribolab\/wp-json\/wp\/v2\/posts\/1262\/revisions"}],"predecessor-version":[{"id":1263,"href":"https:\/\/sisu.ut.ee\/ribolab\/wp-json\/wp\/v2\/posts\/1262\/revisions\/1263"}],"wp:attachment":[{"href":"https:\/\/sisu.ut.ee\/ribolab\/wp-json\/wp\/v2\/media?parent=1262"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sisu.ut.ee\/ribolab\/wp-json\/wp\/v2\/categories?post=1262"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sisu.ut.ee\/ribolab\/wp-json\/wp\/v2\/tags?post=1262"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}