{"id":145,"date":"2025-10-07T15:52:48","date_gmt":"2025-10-07T12:52:48","guid":{"rendered":"https:\/\/sisu.ut.ee\/rakera\/rakera-tegevussuunad\/"},"modified":"2025-10-22T13:50:33","modified_gmt":"2025-10-22T10:50:33","slug":"rakera-tegevussuunad","status":"publish","type":"page","link":"https:\/\/sisu.ut.ee\/rakera\/en\/rakera-tegevussuunad\/","title":{"rendered":"Activity Areas"},"content":{"rendered":"
Activity Area<\/th>Detailed Information<\/th>Lead Institution<\/th>Participants<\/th><\/tr><\/thead>
I-I Design, construction and optimization of microbial cell factories for the synthesis of novel biomaterials<\/strong><\/td>\u2022 Design of organisms with new properties
\u2022 Creation of new expression strains and reporter systems
\u2022 Production of bioactive compounds using microbes<\/td>		UT MRI<\/td>T. Tamm, I. Faustova, M. Kivisaar, K. Mark<\/td><\/tr>
I-II Determination of bioactive compound activity, design of methods and model systems<\/strong><\/td>\u2022 Exploration and characterization of microbial communities
\u2022 Screening and evaluation of bioactive compound efficacy
\u2022 Methods for studying pathogenic fungi and antimicrobial compounds<\/td>		EMU PKI<\/td>K. Mark, K. Loit, R. Drenkhan, T. Tamm, R. H\u00f5rak, H. Tamman, T. Visnapuu, A. Ivask, M. Kivisaar<\/td><\/tr>
I-III Application of microbes in environmental remediation and monitoring<\/strong><\/td>\u2022 Characterization of biodegradation pathways and microbial selection
\u2022 Marker systems for environmental monitoring and ecosystem restoration<\/td>		UT MRI<\/td>M. Kivisaar, J. Truu, K. Mark, R. Drenkhan<\/td><\/tr>
I-IV Monitoring of microbial pathogens in food and environmental samples<\/strong><\/td>\u2022 Detection of pathogens in food and the environment
\u2022 Analysis and sorting of emulsion systems in biotechnology<\/td>		UT MRI<\/td>M. Remm, J. Truu, O. Scheler<\/td><\/tr>
II-I Cellular energetics and metabolism \u2013 applications in cancer therapy and cardiovascular disease treatment<\/strong><\/td>\u2022 Studies on metabolism and ion exchange in cancer and cardiac cells
\u2022 Development of gene and cell therapy drugs<\/td>		NICPB<\/td>T. K\u00e4\u00e4mbre, M. Vendelin, T. Maimets<\/td><\/tr>
II-II Cellular processes enhancing immune defense, development of vaccines and RNA therapeutics<\/strong><\/td>\u2022 Modulation of inflammation and wound healing processes
\u2022 mRNA vaccine technologies and virus\u2013host interactions<\/td>		TU LTI<\/td>R. Tuvikene, A. Merits, T. Lehto<\/td><\/tr>
II-III Analysis of cell populations and studies of neuronal processes for therapy development<\/strong><\/td>\u2022 Single-cell sequencing and marker validation
\u2022 Application of neuronal co-cultures in gene therapy research<\/td>		TalTech KBI<\/td>A. Velthut-Meikas, I. Koppel, T. Timmusk<\/td><\/tr>
II-IV Development of nucleic acid-based drug delivery and gene expression systems (for prevention of neurodegenerative diseases)<\/strong><\/td>\u2022 Analysis of delivery mechanisms and safety
\u2022 Use of CRISPR-Cas and peptide compounds for gene expression modulation
\u2022 Anti-amyloid and metal-chelating drugs<\/td>		UT TI<\/td>T. Lehto, M. Pooga, T. Timmusk, I. Koppel, P. Palumaa<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

UT BI<\/strong> \u2013 Institute of Bioengineering, University of Tartu
UT TI<\/strong> \u2013 Institute of Technology, University of Tartu
UT MRI<\/strong> \u2013 Institute of Molecular and Cell Biology, University of Tartu
TalTech KBI<\/strong> \u2013 Department of Chemistry and Biotechnology, Tallinn University of Technology
TU LTI<\/strong> \u2013 School of Natural and Health Sciences, Tallinn University
EMU PKI<\/strong> \u2013 Institute of Agricultural and Environmental Sciences, Estonian University of Life Sciences
NICPB<\/strong> \u2013 National Institute of Chemical Physics and Biophysics<\/p>\n","protected":false},"excerpt":{"rendered":"

Activity Area Detailed Information Lead Institution Participants I-I Design, construction and optimization of microbial cell factories for the synthesis of novel biomaterials \u2022 Design of organisms with new properties\u2022 Creation of new expression strains and reporter systems\u2022 Production of bioactive …<\/p>\n","protected":false},"author":911,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-145","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/sisu.ut.ee\/rakera\/en\/wp-json\/wp\/v2\/pages\/145","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sisu.ut.ee\/rakera\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sisu.ut.ee\/rakera\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sisu.ut.ee\/rakera\/en\/wp-json\/wp\/v2\/users\/911"}],"replies":[{"embeddable":true,"href":"https:\/\/sisu.ut.ee\/rakera\/en\/wp-json\/wp\/v2\/comments?post=145"}],"version-history":[{"count":1,"href":"https:\/\/sisu.ut.ee\/rakera\/en\/wp-json\/wp\/v2\/pages\/145\/revisions"}],"predecessor-version":[{"id":148,"href":"https:\/\/sisu.ut.ee\/rakera\/en\/wp-json\/wp\/v2\/pages\/145\/revisions\/148"}],"wp:attachment":[{"href":"https:\/\/sisu.ut.ee\/rakera\/en\/wp-json\/wp\/v2\/media?parent=145"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}