{"id":14,"date":"2024-04-04T00:39:46","date_gmt":"2024-04-03T21:39:46","guid":{"rendered":"https:\/\/sisu.ut.ee\/lcms_method_validation\/14-valchrom\/"},"modified":"2025-12-19T16:08:50","modified_gmt":"2025-12-19T14:08:50","slug":"14-valchrom","status":"publish","type":"page","link":"https:\/\/sisu.ut.ee\/lcms_method_validation\/14-valchrom\/","title":{"rendered":"1.4. ValChrom"},"content":{"rendered":"

\"logo\"Introduction<\/h2>\n

ValChrom is an online software tool for the validation of chromatographic analysis methods, which currently implements validation guidelines from 3 international organizations (Eurachem [ref 3], EMA [ref 7], ICH [ref 17]). ValChrom lets the user choose between validation guidelines, specify validation parameters and the ways how the validation parameters are assessed. This information is used by the system for creating the Validation Plan Template<\/strong>, where the way the calculations should be done is determined. The\u00a0Experimental Plan<\/strong> is a detailed description of the experiments that have to be performed in the laboratory, built based on validation plan template. After performing the planned experiments, the user enters the experimental data into Experimental Dataset<\/strong>. Using this\u00a0data, ValChrom calculates the required validation parameters and creates a validation report.<\/p>\n

In this course ValChrom can be used (not mandatory) as a learning aid in parallel to or instead of spreadsheet programs. There are also some bonus self-tests (not graded tests) that are meant to be solved using only ValChrom (e.g. CC\u03b1<\/sub> and CC\u03b2<\/sub> calculation).<\/p>\n

ValChrom is still under development. Any feedback on how to improve the software or any suggestions for additional functionality is greatly appreciated at valchrom@ut.ee or +372 737 6030.<\/p>\n

The flowchart of ValChrom is presented below.<\/p>\n

\"flowchart\"<\/p>\n

Signing up\/logging in<\/h2>\n
    \n
  1. Go to https:\/\/valchrom.ut.ee<\/a><\/li>\n
  2. Create a user account using the Sign up option. Username is an email address. Please use your real e-mail address, so we can inform you about major updates.<\/li>\n<\/ol>\n

    \"1.4.2\"<\/p>\n

    Inside ValChrom<\/h2>\n

    When logged in to ValChrom you are directed to dashboard with the flowchart of ValChrom.<\/p>\n

    \"1.4.3\"<\/p>\n

    The sections depicted in the flowchart are accessible in the upper right corner, under \u201cSections\u201d. In this tutorial we will visit 4 sections: Analytical Methods, Validation Plan Templates, Experimental Plan and Experimental dataset.\u00a0For help look in the Help menu or specific view\u00b4s green questionmark.<\/p>\n

    \"help\"<\/p>\n

    Analytical Methods<\/h2>\n

    This part of the software is used to describe the analytical method that is validated. You are welcome to create as many method descriptions as you like, but in order to follow this tutorial and solve ValChrom-based self-tests in this course, please follow the instructions below precisely<\/strong>.<\/p>\n

    1. Sections > Analytical Methods.
    2. Click on the large + sign at the lower right corner of the window. \u00a0\"+\"
    3. Insert Method name: MOOC method<\/strong>
    4. Insert Concentration unit: ppm<\/strong>
    5. Insert Area unit: kcount*s<\/strong>
    6. Insert Retention time unit: min<\/strong>
    7. Insert Description: Sample method used in MOOC self-tests<\/strong>.
    8. In section \u201cAdd Analyte\u201d insert:<\/p>\n