{"id":1153,"date":"2024-04-11T14:13:59","date_gmt":"2024-04-11T11:13:59","guid":{"rendered":"https:\/\/sisu.ut.ee\/lcms_method_validation\/self-test-4-4c\/"},"modified":"2024-04-11T14:13:59","modified_gmt":"2024-04-11T11:13:59","slug":"self-test-4-4c","status":"publish","type":"page","link":"https:\/\/sisu.ut.ee\/lcms_method_validation\/self-test-4-4c\/","title":{"rendered":"Self-test 4.4C"},"content":{"rendered":"<div id=\"watupro_quiz\" class=\"quiz-area single-page-quiz\">\n<p id=\"submittingExam16\" style=\"display:none;text-align:center;\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/sisu.ut.ee\/wp-content\/plugins\/watupro\/img\/loading.gif\" width=\"16\" height=\"16\"><\/p>\n\n\n\n<form action=\"\" method=\"post\" class=\"quiz-form\" id=\"quiz-16\" enctype=\"multipart\/form-data\">\n<div class=\"watu-question \" id=\"question-1\" style=\";\"><div id=\"questionWrap-1\" class=\"   watupro-question-id-54\">\n\t\t\t<div class=\"question-content\"><div><span class=\"watupro_num\">1. <\/span>Mark the correct statements! (<em>s<\/em><sub>r<\/sub> \u2013 SD of repeatability, <em>s<\/em><sub>R<\/sub> \u2013 SD of intermediate precision, <em>u<\/em><sub>c<\/sub> \u2013 measurement uncertainty).<\/div><input type=\"hidden\" name=\"question_id[]\" id=\"qID_1\" value=\"54\" class=\"watupro-question-id\"><input type=\"hidden\" id=\"answerType54\" class=\"answerTypeCnt1\" value=\"checkbox\"><!-- end question-content--><\/div><div class=\"question-choices watupro-choices-columns \" id=\"questionChoices54\"><div class=\"watupro-question-choice  \" dir=\"auto\"><input type=\"checkbox\" name=\"answer-54[]\" id=\"answer-id-150\" class=\"answer   answerof-54 \" value=\"150\"><label for=\"answer-id-150\" id=\"answer-label-150\" class=\" answer\"><span><p><em>s<\/em><sub>r<\/sub> &gt; \u00a0<em>s<\/em><sub>R<\/sub><\/p><\/span><\/label><\/div><div class=\"watupro-question-choice  \" dir=\"auto\"><input type=\"checkbox\" name=\"answer-54[]\" id=\"answer-id-151\" class=\"answer   answerof-54 \" value=\"151\"><label for=\"answer-id-151\" id=\"answer-label-151\" class=\" answer\"><span><p><em>s<\/em><sub>r<\/sub> &lt; \u00a0<em>s<\/em><sub>R<\/sub><\/p><\/span><\/label><\/div><div class=\"watupro-question-choice  \" dir=\"auto\"><input type=\"checkbox\" name=\"answer-54[]\" id=\"answer-id-152\" class=\"answer   answerof-54 \" value=\"152\"><label for=\"answer-id-152\" id=\"answer-label-152\" class=\" answer\"><span><p><em>s<\/em><sub>R<\/sub> &lt; <em>u<\/em><sub>c<\/sub>\u00a0<\/p><\/span><\/label><\/div><div class=\"watupro-question-choice  \" dir=\"auto\"><input type=\"checkbox\" name=\"answer-54[]\" id=\"answer-id-153\" class=\"answer   answerof-54 \" value=\"153\"><label for=\"answer-id-153\" id=\"answer-label-153\" class=\" answer\"><span><p><em>s<\/em><sub>r<\/sub> &gt; <em>u<\/em><sub>c<\/sub>\u00a0<\/p><\/span><\/label><\/div><!-- end question-choices--><\/div><!-- end questionWrap--><\/div>\t\t\t\t\t<div style=\"display:none;\" id=\"liveResult-1\">\t\t   \n\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/sisu.ut.ee\/wp-content\/plugins\/watupro\/img\/loading.gif\" width=\"16\" height=\"16\" alt=\"Loading...\" title=\"Loading...\">\u00a0Loading...\t\t\t\t\t<\/div>\t\n\t\t\t<\/div> \n\t   \t<p id=\"liveResBtn-54\" style=\"clear:both;\"><input type=\"button\" id=\"liveResultBtn54\" class=\"liveResultBtn1 watupro-live-result-btn\" value=\"See Answer\" onclick=\"WatuPRO.liveResult(54, 1);\"><\/p>\n\t   <div class=\"watu-question \" id=\"question-2\" style=\";\"><div class=\"watupro-question-intro\">An analyst intended to determine the repeatability of the method. He analyzed a food sample by LC-MS. He carefully homogenized the sample in a blender and took a subsample. With the subsample he carried out sample preparation (consisting of extraction, precipitation and centrifugation). As a result he obtained a clear solution. He transferred it into a 100 mL volumetric flask and filled it up to the mark with the mobile phase. He analyzed 10 aliquots of this solution during the same day and calculated the repeatability as standard deviation of the results.<br>\r\n<br>\r\n<\/div><div id=\"questionWrap-2\" class=\"   watupro-question-id-53\">\n\t\t\t<div class=\"question-content\"><div><span class=\"watupro_num\">2. <\/span>What did he actually determine?<\/div><input type=\"hidden\" name=\"question_id[]\" id=\"qID_2\" value=\"53\" class=\"watupro-question-id\"><input type=\"hidden\" id=\"answerType53\" class=\"answerTypeCnt2\" value=\"checkbox\"><!-- end question-content--><\/div><div class=\"question-choices watupro-choices-columns \" id=\"questionChoices53\"><div class=\"watupro-question-choice  \" dir=\"auto\"><input type=\"checkbox\" name=\"answer-53[]\" id=\"answer-id-145\" class=\"answer   answerof-53 \" value=\"145\"><label for=\"answer-id-145\" id=\"answer-label-145\" class=\" answer\"><span><p>Bias<\/p><\/span><\/label><\/div><div class=\"watupro-question-choice  \" dir=\"auto\"><input type=\"checkbox\" name=\"answer-53[]\" id=\"answer-id-146\" class=\"answer   answerof-53 \" value=\"146\"><label for=\"answer-id-146\" id=\"answer-label-146\" class=\" answer\"><span><p>Intermediate precision of the method\u00a0<\/p><\/span><\/label><\/div><div class=\"watupro-question-choice  \" dir=\"auto\"><input type=\"checkbox\" name=\"answer-53[]\" id=\"answer-id-147\" class=\"answer   answerof-53 \" value=\"147\"><label for=\"answer-id-147\" id=\"answer-label-147\" class=\" answer\"><span><p>Repeatability of the method<\/p><\/span><\/label><\/div><div class=\"watupro-question-choice  \" dir=\"auto\"><input type=\"checkbox\" name=\"answer-53[]\" id=\"answer-id-148\" class=\"answer   answerof-53 \" value=\"148\"><label for=\"answer-id-148\" id=\"answer-label-148\" class=\" answer\"><span><p>Repeatability of the analysis step of the method\u00a0<\/p><\/span><\/label><\/div><div class=\"watupro-question-choice  \" dir=\"auto\"><input type=\"checkbox\" name=\"answer-53[]\" id=\"answer-id-149\" class=\"answer   answerof-53 \" value=\"149\"><label for=\"answer-id-149\" id=\"answer-label-149\" class=\" answer\"><span><p>Repeatability of sample preparation\u00a0<\/p><\/span><\/label><\/div><!-- end question-choices--><\/div><!-- end questionWrap--><\/div>\t\t\t\t\t<div style=\"display:none;\" id=\"liveResult-2\">\t\t   \n\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/sisu.ut.ee\/wp-content\/plugins\/watupro\/img\/loading.gif\" width=\"16\" height=\"16\" alt=\"Loading...\" title=\"Loading...\">\u00a0Loading...\t\t\t\t\t<\/div>\t\n\t\t\t<\/div> \n\t   \t<p id=\"liveResBtn-53\" style=\"clear:both;\"><input type=\"button\" id=\"liveResultBtn53\" class=\"liveResultBtn2 watupro-live-result-btn\" value=\"See Answer\" onclick=\"WatuPRO.liveResult(53, 2);\"><\/p>\n\t   <div class=\"watu-question \" id=\"question-3\" style=\";\"><div class=\"watupro-question-intro\">An analyst intended to determine the trueness of the method. He analyzed a food sample by LC-MS. He carefully homogenized the sample in a blender and divided it into 10 subsamples and added a known amount of standard solution in each subsample. With the subsamples he carried out sample preparation (consisting of extraction, precipitation and centrifugation). As a result he obtained a clear solutions that he diluted to 1 mL with mobile phase. He analyzed all samples during the same day and divided the mean analyte amount detected by the analyte amount added to the sample.<br>\r\n<br>\r\n<\/div><div id=\"questionWrap-3\" class=\"   watupro-question-id-56\">\n\t\t\t<div class=\"question-content\"><div><span class=\"watupro_num\">3. <\/span>What did he actually determine?<\/div><input type=\"hidden\" name=\"question_id[]\" id=\"qID_3\" value=\"56\" class=\"watupro-question-id\"><input type=\"hidden\" id=\"answerType56\" class=\"answerTypeCnt3\" value=\"checkbox\"><!-- end question-content--><\/div><div class=\"question-choices watupro-choices-columns \" id=\"questionChoices56\"><div class=\"watupro-question-choice  \" dir=\"auto\"><input type=\"checkbox\" name=\"answer-56[]\" id=\"answer-id-154\" class=\"answer   answerof-56 \" value=\"154\"><label for=\"answer-id-154\" id=\"answer-label-154\" class=\" answer\"><span><p>Bias<\/p><\/span><\/label><\/div><div class=\"watupro-question-choice  \" dir=\"auto\"><input type=\"checkbox\" name=\"answer-56[]\" id=\"answer-id-155\" class=\"answer   answerof-56 \" value=\"155\"><label for=\"answer-id-155\" id=\"answer-label-155\" class=\" answer\"><span><p>Recovery<\/p><\/span><\/label><\/div><div class=\"watupro-question-choice  \" dir=\"auto\"><input type=\"checkbox\" name=\"answer-56[]\" id=\"answer-id-156\" class=\"answer   answerof-56 \" value=\"156\"><label for=\"answer-id-156\" id=\"answer-label-156\" class=\" answer\"><span><p>Process efficiency\u00a0<\/p><\/span><\/label><\/div><div class=\"watupro-question-choice  \" dir=\"auto\"><input type=\"checkbox\" name=\"answer-56[]\" id=\"answer-id-157\" class=\"answer   answerof-56 \" value=\"157\"><label for=\"answer-id-157\" id=\"answer-label-157\" class=\" answer\"><span><p>Matrix effect\u00a0<\/p><\/span><\/label><\/div><!-- end question-choices--><\/div><!-- end questionWrap--><\/div>\t\t\t\t\t<div style=\"display:none;\" id=\"liveResult-3\">\t\t   \n\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/sisu.ut.ee\/wp-content\/plugins\/watupro\/img\/loading.gif\" width=\"16\" height=\"16\" alt=\"Loading...\" title=\"Loading...\">\u00a0Loading...\t\t\t\t\t<\/div>\t\n\t\t\t<\/div> \n\t   \t<p id=\"liveResBtn-56\" style=\"clear:both;\"><input type=\"button\" id=\"liveResultBtn56\" class=\"liveResultBtn3 watupro-live-result-btn\" value=\"See Answer\" onclick=\"WatuPRO.liveResult(56, 3);\"><\/p>\n\t   <div class=\"watu-question \" id=\"question-4\" style=\";\"><div id=\"questionWrap-4\" class=\"   watupro-question-id-57\">\n\t\t\t<div class=\"question-content\"><div><span class=\"watupro_num\">4. <\/span>What other validation parameters can be evaluated from the results?<\/div><input type=\"hidden\" name=\"question_id[]\" id=\"qID_4\" value=\"57\" class=\"watupro-question-id\"><input type=\"hidden\" id=\"answerType57\" class=\"answerTypeCnt4\" value=\"checkbox\"><!-- end question-content--><\/div><div class=\"question-choices watupro-choices-columns \" id=\"questionChoices57\"><div class=\"watupro-question-choice  \" dir=\"auto\"><input type=\"checkbox\" name=\"answer-57[]\" id=\"answer-id-158\" class=\"answer   answerof-57 \" value=\"158\"><label for=\"answer-id-158\" id=\"answer-label-158\" class=\" answer\"><span><p>Intermediate precision of the method\u00a0<\/p><\/span><\/label><\/div><div class=\"watupro-question-choice  \" dir=\"auto\"><input type=\"checkbox\" name=\"answer-57[]\" id=\"answer-id-159\" class=\"answer   answerof-57 \" value=\"159\"><label for=\"answer-id-159\" id=\"answer-label-159\" class=\" answer\"><span><p>Repeatability of the method\u00a0<\/p><\/span><\/label><\/div><div class=\"watupro-question-choice  \" dir=\"auto\"><input type=\"checkbox\" name=\"answer-57[]\" id=\"answer-id-160\" class=\"answer   answerof-57 \" value=\"160\"><label for=\"answer-id-160\" id=\"answer-label-160\" class=\" answer\"><span><p>Limit of quantification\u00a0<\/p><\/span><\/label><\/div><div class=\"watupro-question-choice  \" dir=\"auto\"><input type=\"checkbox\" name=\"answer-57[]\" id=\"answer-id-161\" class=\"answer   answerof-57 \" value=\"161\"><label for=\"answer-id-161\" id=\"answer-label-161\" class=\" answer\"><span><p>Robustness<\/p><\/span><\/label><\/div><!-- end question-choices--><\/div><!-- end questionWrap--><\/div>\t\t\t\t\t<div style=\"display:none;\" id=\"liveResult-4\">\t\t   \n\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/sisu.ut.ee\/wp-content\/plugins\/watupro\/img\/loading.gif\" width=\"16\" height=\"16\" alt=\"Loading...\" title=\"Loading...\">\u00a0Loading...\t\t\t\t\t<\/div>\t\n\t\t\t<\/div> \n\t   \t<p id=\"liveResBtn-57\" style=\"clear:both;\"><input type=\"button\" id=\"liveResultBtn57\" class=\"liveResultBtn4 watupro-live-result-btn\" value=\"See Answer\" onclick=\"WatuPRO.liveResult(57, 4);\"><\/p>\n\t   <div style=\"display:none\" id=\"question-5\">\n\t<div class=\"question-content\">\n\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/sisu.ut.ee\/wp-content\/plugins\/watupro\/img\/loading.gif\" width=\"16\" height=\"16\" alt=\"Loading...\" title=\"Loading...\">\u00a0Loading...\t<\/div>\n<\/div>\n\n<br>\n\t\n\t\t\t<div class=\"watupro_buttons flex \" id=\"watuPROButtons16\">\n\t\t  <div id=\"prev-question\" style=\"display:none;\"><input type=\"button\" value=\"&lt; Previous\" onclick=\"WatuPRO.nextQuestion(event, 'previous');\"><\/div>\t\t  \t\t  \t\t   \n\t\t   \t  \t\t<div><input type=\"button\" name=\"action\" class=\"watupro-submit-button\" onclick=\"WatuPRO.submitResult(event)\" id=\"action-button\" value=\"View Results\">\n\t\t<\/div>\n\t\t<\/div>\n\t\t\n\t<input type=\"hidden\" name=\"quiz_id\" value=\"16\" id=\"watuPROExamID\">\n\t<input type=\"hidden\" name=\"start_time\" id=\"startTime\" value=\"2026-04-17 09:11:37\">\n\t<input type=\"hidden\" name=\"start_timestamp\" id=\"startTimeStamp\" value=\"1776417097\">\n\t<input type=\"hidden\" name=\"question_ids\" value=\"\">\n\t<input 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