MOOC: Validation of liquid chromatography mass spectrometry (LC-MS) methods (analytical chemistry) course
6. Precision and trueness: some additional aspects
In the preceding sections the concepts of and as well as their practical evaluation were explained. This section examines some additional aspects of trueness and precision determination. The experiments for precision and trueness evaluation are often carried out in parallel (simultaneously). If this is not the case, then before trueness experiments, precision of the method must be checked. This is because precision influences the evaluation of trueness (or its constituents), but not vice versa.
In this section you will find practical information on how to choose the sample types, concentration levels, numbers of replicates and time ranges for precision evaluation (section 6.1), but also how to find reference values for calculations (section 6.2). Section 6.3 discusses how to decide whether or not to correct results for bias.
Practical aspects of precision and trueness: Different guidelines
http://www.uttv.ee/naita?id=23633
https://www.youtube.com/watch?v=pObPZYAMdtE