{"id":5,"date":"2024-04-04T02:59:08","date_gmt":"2024-04-03T23:59:08","guid":{"rendered":"https:\/\/sisu.ut.ee\/gentransmed\/human-disease-genomics-research-group\/"},"modified":"2024-04-04T02:59:17","modified_gmt":"2024-04-03T23:59:17","slug":"human-disease-genomics-research-group","status":"publish","type":"page","link":"https:\/\/sisu.ut.ee\/gentransmed\/human-disease-genomics-research-group\/","title":{"rendered":"Human Disease Genomics Research Group"},"content":{"rendered":"<p><strong>Human Disease Genomics Research Group<\/strong> <br>The research of the Human Disease Genomics group at Estonian Genome Center is focused on understanding the role of genetic variation in health and disease. The group develops novel computational tools and analytical methods, investigates a wide range of health conditions and behaviors, and aims to better understand ethical and practical challenges in implementing genomics into general healthcare. The Human Disease Genomics group is an active member of many international genetic association consortia and has contributed to the discovery of hundreds of genetic risk factors or modifiers for many health outcomes. As multi-phenotype analysis of several correlated traits have been shown to have larger statistical power compared to single phenotype analysis, we are also working on software tools for multi phenotype analysis, which uses inverted regression framework, where genotype is considered as outcome and phenotypes are used as independent variables, and also its meta-analysis tool, which combines data considering inter-phenotype covariance matrices. <br>Obesity is one of the most common modifiable disease risk factor and it has became a world-wide epidemic and one of the largest burdens to medical systems. Our main research questions are mostly concerning the genetics of obesity and obesity related cardio-metabolic diseases, including coronary heart disease, type 2 diabetes, myocardial infarction, hypertension etc. We are collaborating in several international consortia, including CARDIOGRAM, DIAGRAM, MAGIC to identify additional genetic variants associated with these diseases, as well as working on the disease risk prediction algorithms based on the generated data, which can be used in genomic counseling and disease prevention programs.<\/p>\n<p><strong>Research and teaching<br><\/strong>Andres Metspalu, MD; PhD (group leader) <br>Krista Fischer, PhD, Senior Researcher <br>Lili Milani, PhD, Senior Researcher <br>Reedik M\u00e4gi, PhD, Senior Researcher <br>Andrew Morris, PhD, Visiting Professor <br>Paula-Ann Kivistik, PhD, Head of Sequencing <br>Nele Taba, MSc, Specialist<\/p>\n<p><strong>PhD Students<\/strong> <br>Mart Kals, MSc Kristi L\u00e4ll, MSc <br>Silva Kasela, MSc Natalia Perjakova, <br>MSc Viktoria Kukuskina, <br>MSc T\u00f5nis Tasa, MSc <br>Maarja Lepamets, MSc <br>Mario Mitt, MSc <br>Kristi Krebs, MSc <br>Kelli Grand, MSc <br>Riin Tamm, MSc <br>Anu Tammiste, MSc<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Human Disease Genomics Research Group The research of the Human Disease Genomics group at Estonian Genome Center is focused on understanding the role of genetic variation in health and disease. The group develops novel computational tools and analytical methods, investigates &#8230;<\/p>\n","protected":false},"author":90,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-5","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/sisu.ut.ee\/gentransmed\/wp-json\/wp\/v2\/pages\/5","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sisu.ut.ee\/gentransmed\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sisu.ut.ee\/gentransmed\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sisu.ut.ee\/gentransmed\/wp-json\/wp\/v2\/users\/90"}],"replies":[{"embeddable":true,"href":"https:\/\/sisu.ut.ee\/gentransmed\/wp-json\/wp\/v2\/comments?post=5"}],"version-history":[{"count":1,"href":"https:\/\/sisu.ut.ee\/gentransmed\/wp-json\/wp\/v2\/pages\/5\/revisions"}],"predecessor-version":[{"id":61,"href":"https:\/\/sisu.ut.ee\/gentransmed\/wp-json\/wp\/v2\/pages\/5\/revisions\/61"}],"wp:attachment":[{"href":"https:\/\/sisu.ut.ee\/gentransmed\/wp-json\/wp\/v2\/media?parent=5"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}