{"id":14,"date":"2024-04-04T03:12:59","date_gmt":"2024-04-04T00:12:59","guid":{"rendered":"https:\/\/sisu.ut.ee\/cemce\/engineering-biosynthesis-pathways-and-circuits\/"},"modified":"2024-04-04T03:15:01","modified_gmt":"2024-04-04T00:15:01","slug":"engineering-biosynthesis-pathways-and-circuits","status":"publish","type":"page","link":"https:\/\/sisu.ut.ee\/cemce\/engineering-biosynthesis-pathways-and-circuits\/","title":{"rendered":"Engineering biosynthesis pathways and circuits"},"content":{"rendered":"
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WP leader<\/strong>:<\/strong> Mart Loog <\/span><\/p>\n

General concept. <\/strong>New pathways for the production of biomolecules (biochemicals, antibodies, other proteins) will be introduced into bacterial, yeast, plant and mammalian cells.\u00a0<\/span><\/p>\n

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Projects<\/strong><\/p>\n

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  • A1. Engineering protein production pathways\u00a0<\/li>\n
  • A2. Synthetic protein tags and regulatory circuits\u00a0<\/li>\n
  • A3. Engineering the isoprenoid biosynthesis pathway<\/li>\n<\/ul>\n
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    Long\u2010term goal<\/strong><\/p>\n

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    To create a platform that would enable engineering of metabolic pathways. This will be achieved by transferring genes into standard expression platforms (bacterial, yeast, plant, and mammalian cells). Computational molecular engineering and molecular informatics\u2010guided protein engineering together with experimental evolution will be used in modifying existing enzymatic activities and designing enzymes with new activities. Biological engineering for the production of biological molecules will be combined with organic synthesis where needed. This approach is expected to provide streamlined green chemistry solutions for chemical production.\u00a0<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

    WP leader: Mart Loog General concept. New pathways for the production of biomolecules (biochemicals, antibodies, other proteins) will be introduced into bacterial, yeast, plant and mammalian cells.\u00a0 Projects A1. Engineering protein production pathways\u00a0 A2. Synthetic protein tags and regulatory circuits\u00a0 …<\/p>\n","protected":false},"author":39,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-14","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/sisu.ut.ee\/cemce\/wp-json\/wp\/v2\/pages\/14","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sisu.ut.ee\/cemce\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sisu.ut.ee\/cemce\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sisu.ut.ee\/cemce\/wp-json\/wp\/v2\/users\/39"}],"replies":[{"embeddable":true,"href":"https:\/\/sisu.ut.ee\/cemce\/wp-json\/wp\/v2\/comments?post=14"}],"version-history":[{"count":1,"href":"https:\/\/sisu.ut.ee\/cemce\/wp-json\/wp\/v2\/pages\/14\/revisions"}],"predecessor-version":[{"id":407,"href":"https:\/\/sisu.ut.ee\/cemce\/wp-json\/wp\/v2\/pages\/14\/revisions\/407"}],"wp:attachment":[{"href":"https:\/\/sisu.ut.ee\/cemce\/wp-json\/wp\/v2\/media?parent=14"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}