{"id":8,"date":"2024-04-03T23:11:00","date_gmt":"2024-04-03T20:11:00","guid":{"rendered":"https:\/\/sisu.ut.ee\/antikehad\/23-inimese-monokloonsed-antikehad\/"},"modified":"2024-04-03T23:11:04","modified_gmt":"2024-04-03T20:11:04","slug":"23-inimese-monokloonsed-antikehad","status":"publish","type":"page","link":"https:\/\/sisu.ut.ee\/antikehad\/23-inimese-monokloonsed-antikehad\/","title":{"rendered":"2.3. Inimese monokloonsed antikehad"},"content":{"rendered":"<p>Terapeutiliste antikehade arendamisel eelistakse kandidaadina inimese Ig geenide poolt kodeeritud antikehi, seda nii v\u00e4iksema immunogeensuse, pikema poolv\u00e4\u00e4rtusaja kui ka t\u00f5husamate efektorfunktsioonide poolest v\u00f5rreldes hiire v\u00f5i kim\u00e4\u00e4rsete\/humaniseeritud antikehadega. Teiste s\u00f5nadega, inimese terapeutiliste antikehade farmakokineetilised (kuidas organism m\u00f5jutab ravimit)\u00a0\u00a0ja farmakod\u00fcnaamilised (kuidas ravim m\u00f5jutab organismi)\u00a0\u00a0omadused v\u00f5iksid olla paremad mitte-inimp\u00e4ritolu antikehade vastavatest omadustest.<\/p>\n<p>Inimesi ei saa eetilistel p\u00f5hjustel immuniseerida teaduslikel eesm\u00e4rkidel, sellep\u00e4rast on t\u00f6\u00f6tatud v\u00e4lja mitmesugused l\u00e4henemised inimese monokloonsete antikehade saamiseks. Meetodeid v\u00f5ib jagada\u00a0\u00a0kombinatoorseteks ja mittekombinatoorseteks. Kombinatoorseteks meetoditeks on erinevatel kandjatel kuvatud rekombinantsete antikeha-raamatukogude kasutamine. Mittekombinatoorseteks meetoditeks on h\u00fcbridoomi meetodi kasutamine inimese Ig geenidega transgeensetel loomadel v\u00f5i antikehade kloneerimine (loomulikult immuniseeritud v\u00f5i vaktsineeritud) patsientide B-rakkudest.\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Terapeutiliste antikehade arendamisel eelistakse kandidaadina inimese Ig geenide poolt kodeeritud antikehi, seda nii v\u00e4iksema immunogeensuse, pikema poolv\u00e4\u00e4rtusaja kui ka t\u00f5husamate efektorfunktsioonide poolest v\u00f5rreldes hiire v\u00f5i kim\u00e4\u00e4rsete\/humaniseeritud antikehadega. Teiste s\u00f5nadega, inimese terapeutiliste antikehade farmakokineetilised (kuidas organism m\u00f5jutab ravimit)\u00a0\u00a0ja farmakod\u00fcnaamilised (kuidas ravim &#8230;<\/p>\n","protected":false},"author":280,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-8","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/sisu.ut.ee\/antikehad\/wp-json\/wp\/v2\/pages\/8","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sisu.ut.ee\/antikehad\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sisu.ut.ee\/antikehad\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sisu.ut.ee\/antikehad\/wp-json\/wp\/v2\/users\/280"}],"replies":[{"embeddable":true,"href":"https:\/\/sisu.ut.ee\/antikehad\/wp-json\/wp\/v2\/comments?post=8"}],"version-history":[{"count":1,"href":"https:\/\/sisu.ut.ee\/antikehad\/wp-json\/wp\/v2\/pages\/8\/revisions"}],"predecessor-version":[{"id":64,"href":"https:\/\/sisu.ut.ee\/antikehad\/wp-json\/wp\/v2\/pages\/8\/revisions\/64"}],"wp:attachment":[{"href":"https:\/\/sisu.ut.ee\/antikehad\/wp-json\/wp\/v2\/media?parent=8"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}