{"id":5,"date":"2024-04-03T23:11:00","date_gmt":"2024-04-03T20:11:00","guid":{"rendered":"https:\/\/sisu.ut.ee\/antikehad\/2-terapeutiliste-antikehade-saamisviisid\/"},"modified":"2024-04-10T10:04:07","modified_gmt":"2024-04-10T07:04:07","slug":"2-terapeutiliste-antikehade-saamisviisid","status":"publish","type":"page","link":"https:\/\/sisu.ut.ee\/antikehad\/2-terapeutiliste-antikehade-saamisviisid\/","title":{"rendered":"2. Terapeutiliste antikehade saamisviisid"},"content":{"rendered":"<p>Terapeutilised antikehad on immunoglobuliinid v\u00f5i nende fragmendid, mida kasutatakse haiguste ravis. L\u00e4htudes antikehade p\u00e4ritolust, jaotatakse neid pol\u00fckloonseteks ja monokloonseteks antikehadeks. Katselooma immuniseerimisel antigeeniga tekivad erinevate B-rakkude poolt toodetud antikehad, mis tunnevad \u00e4ra erinevaid epitoope antigeeni molekulil. Tekkinud antikehade segu nimetatakse pol\u00fckloonseteks antikehadeks.<\/p>\n<p>Monokloonsed antikehad p\u00e4rinevad \u00fche B-raku j\u00e4rglaskonnast \u00a0(kloonist) ja reageerivad \u00fche epitoobiga antigeeni molekulil. Seega on monokloonsed antikehad omavahel identsed ja kindla seondumisspetsiifikaga, olles seet\u00f5ttu sobivamad kasutamisel ravimina. V\u00e4lja on t\u00f6\u00f6tatud meetodid monokloonsete antikehade eraldamiseks elusorganismist\u00a0 ja antikehade tootmiseks <em style=\"line-height: 1.6em;\">in vitro.<\/em>\u00a0Kitsamas t\u00e4henduses m\u00f5istetaksegi terapeutiliste antikehade all eelk\u00f5ige monokloonseid antikehasid.<\/p>\n<p>L\u00e4htudes antikeha kodeerivate geenide p\u00e4ritolust, eristatatakse 4 t\u00fc\u00fcpi terapeutilisi monokloonseid antikehasid:<\/p>\n<ul>\n<li>katselooma (hiire) monokloonsed antikehad<\/li>\n<li>kim\u00e4\u00e4rsed monokloonsed antikehad<\/li>\n<li>humaniseeritud monokloonsed antikehad<\/li>\n<li>inimese monokloonsed antikehad<\/li>\n<\/ul>\n<p>Terapeutiliste monokloonsete antikehade saamiseks on s\u00f5ltuvalt antikeha t\u00fc\u00fcbist kasutusel erinevaid meetodeid, millest on juttu j\u00e4rgnevates alapeat\u00fckkides.<\/p>\n<h6><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-22\" src=\"https:\/\/sisu.ut.ee\/wp-content\/uploads\/sites\/25\/jata_meelde.png\" alt=\"\" width=\"48\" height=\"48\">J\u00e4ta meelde: pol\u00fckloonsed ja monokloonsed antikehad.<\/h6>\n","protected":false},"excerpt":{"rendered":"<p>Terapeutilised antikehad on immunoglobuliinid v\u00f5i nende fragmendid, mida kasutatakse haiguste ravis. L\u00e4htudes antikehade p\u00e4ritolust, jaotatakse neid pol\u00fckloonseteks ja monokloonseteks antikehadeks. Katselooma immuniseerimisel antigeeniga tekivad erinevate B-rakkude poolt toodetud antikehad, mis tunnevad \u00e4ra erinevaid epitoope antigeeni molekulil. Tekkinud antikehade segu nimetatakse &#8230;<\/p>\n","protected":false},"author":280,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-5","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/sisu.ut.ee\/antikehad\/wp-json\/wp\/v2\/pages\/5","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sisu.ut.ee\/antikehad\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sisu.ut.ee\/antikehad\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sisu.ut.ee\/antikehad\/wp-json\/wp\/v2\/users\/280"}],"replies":[{"embeddable":true,"href":"https:\/\/sisu.ut.ee\/antikehad\/wp-json\/wp\/v2\/comments?post=5"}],"version-history":[{"count":4,"href":"https:\/\/sisu.ut.ee\/antikehad\/wp-json\/wp\/v2\/pages\/5\/revisions"}],"predecessor-version":[{"id":99,"href":"https:\/\/sisu.ut.ee\/antikehad\/wp-json\/wp\/v2\/pages\/5\/revisions\/99"}],"wp:attachment":[{"href":"https:\/\/sisu.ut.ee\/antikehad\/wp-json\/wp\/v2\/media?parent=5"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}